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Dioxin degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase

2-(4''-Chlorophenyl)-3,3-dichloropropenoate <=> 4-chlorophenylacetate not assigned

4-chlorobiphenyl + O2 + NADPH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase

4-oxalocrotonate <=> 2-oxopent-4-enoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase

biphenyl + O2 + NADH + H+ <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase


1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> H+ + 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + Cl- 4.5.1.1 DDT-dehydrochlorinase

cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ <=> 2,3-Dihydroxy-4''-chlorobiphenyl + NADH + H+ 1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase




6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate + H2O <=> 2-(4''-Chlorophenyl)-3,3-dichloropropenoate + (2Z)-3-chloro-2-hydroxypenta-2,4-dienoic_acid 3.7.1

4''-chloro-2,3-dihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase

carbazole + O2 + NADH + H+ <=> 2''-aminobiphenyl-2,3-diol + NAD+ 1.14.12.22 carbazole 1,9a-dioxygenase

H+ + dibenzofuran + NADH + O2 <=> 2,2',3-Trihydroxybiphenyl + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase


2-Hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O <=> 4-Chlorobenzoate + 2-hydroxy-2,4-pentadienoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase

2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H2O <=> 2-hydroxy-2,4-hexadienedioate + catechol + H+ 3.7.1

carbazole + O2 + NADPH + H+ <=> 2''-aminobiphenyl-2,3-diol + NADP+ 1.14.12.22 carbazole 1,9a-dioxygenase

2''-aminobiphenyl-2,3-diol + O2 <=> H+ + (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate 1.13.11
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase


cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ <=> 1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + NADH + H+ 1.3.1

2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate 3.7.1
3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase


2-hydroxy-2,4-hexadienedioate <=> 4-oxalocrotonate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.2.M1


1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + O2 <=> 6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate 1.13.11

2,2'',3-Trihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate 1.13.11

2,2',3-trihydroxybiphenyl_ether + O2 <=> 2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H+ 1.13.11

dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase



(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + 2-hydroxy-2,4-pentadienoate 3.7.1.13 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

biphenyl + NADPH + O2 <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase


O2 + 2,3-Dihydroxybiphenyl <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase


2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> benzoate + 2-oxopent-4-enoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase

4-chlorobiphenyl + O2 + NADH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase

4-oxalocrotonate + H2O <=> 4-hydroxy-2-oxopentanoate + CO2 4.1.1

cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ <=> 2,3-Dihydroxybiphenyl + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase


1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + NADH + H+ + O2 <=> cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12

4-hydroxy-2-oxopentanoate <=> 2-oxopent-4-enoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase

Visualization of the pathway